Biomaterial Database

Tissue specific trisomy--the significance of confined placental mosaicism. 1989

D K Kalousek

Department of Pathology, University of British Columbia, Vancouver, Canada.

Confined placental mosaicism is tissue specific chromosomal mosaicism arising in both chromosomally normal and abnormal zygotes. Studied by first trimester chorionic villus sampling it has been reported in about 1-2% of human gestations. It is more common in the cytotrophoblast than in placental connective tissue. While intrauterine survival of some chromosomally abnormal embryos and fetuses appears to be significantly enhanced by its presence, the effect of confined placental mosaicism on chromosomally normal fetuses is variable and at present time still unpredictable.

UI	MeSH Term	Description	Entries
D008938	Mitosis	A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.	M Phase, Mitotic,Mitotic M Phase,M Phases, Mitotic,Mitoses,Mitotic M Phases,Phase, Mitotic M,Phases, Mitotic M
D009030	Mosaicism	The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
D010920	Placenta	A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).	Placentoma, Normal,Placentome,Placentas,Placentomes
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D002871	Chromosome Banding	Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.	Banding, Chromosome,Bandings, Chromosome,Chromosome Bandings
D002881	Chromosomes, Human, Pair 12	A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.	Chromosome 12
D002882	Chromosomes, Human, Pair 13	A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.	Chromosome 13
D002887	Chromosomes, Human, Pair 18	A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.	Chromosome 18
D002890	Chromosomes, Human, Pair 20	A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.	Chromosome 20
D002896	Chromosomes, Human, Pair 6	A specific pair GROUP C CHROMSOMES of the human chromosome classification.	Chromosome 6