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Testing a combined radiation protection modality: chemical protector and local shielding. 1989

M Minkova, and M Baldzhijska

The impact of combined radiation protection upon damage to critical organs-spleen, small intestine, and bone marrow was studied in adult rat males 3 days after whole-body exposure to 9.5 Gy gamma-ray dose. Adeturone, the chemical radioprotector used, was administered intraperitoneally at 1/17 of its LD50 dose. Local shielding of the abdomino-lumbal region was accomplished using a lead ring providing on average 28-30% attenuation of radiation exposure. This degree of physical abdomino-lumbal protection combined with adeturone (50 mg/kg) pretreatment resulted in mutual enhancement of the components' action, expansion of the chemical agent's therapeutic range, providing a combination with improved overall antiradiation properties.

UI MeSH Term Description Entries
D007854 Lead A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D008297 Male Males
D011835 Radiation Protection Methods and practices adopted to protect against RADIATION. Protection, Radiation
D011837 Radiation-Protective Agents Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. Radiation Protectant,Radiation Protective Agent,Radiation-Protective Agent,Radiation-Protective Drug,Radioprotective Agent,Radioprotective Agents,Radioprotective Drug,Agents, Radiation-Protective,Radiation Protectants,Radiation Protective Agents,Radiation-Protective Drugs,Radiation-Protective Effect,Radiation-Protective Effects,Radioprotective Drugs,Agent, Radiation Protective,Agent, Radiation-Protective,Agent, Radioprotective,Agents, Radiation Protective,Agents, Radioprotective,Drug, Radiation-Protective,Drug, Radioprotective,Drugs, Radiation-Protective,Drugs, Radioprotective,Effect, Radiation-Protective,Effects, Radiation-Protective,Protectant, Radiation,Protectants, Radiation,Protective Agent, Radiation,Protective Agents, Radiation,Radiation Protective Drug,Radiation Protective Drugs,Radiation Protective Effect,Radiation Protective Effects
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D005069 Evaluation Studies as Topic Works about studies that determine the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. Critique,Evaluation Indexes,Evaluation Methodology,Evaluation Report,Evaluation Research,Methodology, Evaluation,Pre-Post Tests,Qualitative Evaluation,Quantitative Evaluation,Theoretical Effectiveness,Use-Effectiveness,Critiques,Effectiveness, Theoretical,Evaluation Methodologies,Evaluation Reports,Evaluation, Qualitative,Evaluation, Quantitative,Evaluations, Qualitative,Evaluations, Quantitative,Indexes, Evaluation,Methodologies, Evaluation,Pre Post Tests,Pre-Post Test,Qualitative Evaluations,Quantitative Evaluations,Report, Evaluation,Reports, Evaluation,Research, Evaluation,Test, Pre-Post,Tests, Pre-Post,Use Effectiveness
D000255 Adenosine Triphosphate An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. ATP,Adenosine Triphosphate, Calcium Salt,Adenosine Triphosphate, Chromium Salt,Adenosine Triphosphate, Magnesium Salt,Adenosine Triphosphate, Manganese Salt,Adenylpyrophosphate,CaATP,CrATP,Manganese Adenosine Triphosphate,MgATP,MnATP,ATP-MgCl2,Adenosine Triphosphate, Chromium Ammonium Salt,Adenosine Triphosphate, Magnesium Chloride,Atriphos,Chromium Adenosine Triphosphate,Cr(H2O)4 ATP,Magnesium Adenosine Triphosphate,Striadyne,ATP MgCl2
D000338 beta-Aminoethyl Isothiourea A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis. 2-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Diacetate,beta-Aminoethylisothiuronium Dihydrobromide,2-Aminoethylisothiuronium Diacetate,2-Aminoethylisothiuronium Dihydrochloride,2-Aminoethylisothiuronium Dihydroiodide,2-Aminoethylisothiuronium Diperchlorate,2-Aminoethylisothiuronium Monohydrobromide,2-Aminoethylisothiuronium Phosphate (1:1),2-Aminoethylisothiuronium Sulfate (1:1),AET,Aminoethylisothiuronium Bromide Hydrobromide,Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide,Isothiourea, (2-Aminoethyl),Ixecur,S-(2-Aminoethyl)isothiourea,beta-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Dihydrochloride,beta-Aminoethylisothiuronium Dihydroiodide,beta-Aminoethylisothiuronium Diperchlorate,beta-Aminoethylisothiuronium Monohydrobromide,beta-Aminoethylisothiuronium Phosphate (1:1),beta-Aminoethylisothiuronium Sulfate (1:1),2 Aminoethylisothiuronium Bromide,2 Aminoethylisothiuronium Diacetate,2 Aminoethylisothiuronium Dihydrochloride,2 Aminoethylisothiuronium Dihydroiodide,2 Aminoethylisothiuronium Diperchlorate,2 Aminoethylisothiuronium Monohydrobromide,Bromide, 2-Aminoethylisothiuronium,Bromide, beta-Aminoethylisothiuronium,Diacetate, 2-Aminoethylisothiuronium,Diacetate, beta-Aminoethylisothiuronium,Dihydrobromide, beta-Aminoethylisothiuronium,Dihydrochloride, 2-Aminoethylisothiuronium,Dihydrochloride, beta-Aminoethylisothiuronium,Dihydroiodide, 2-Aminoethylisothiuronium,Dihydroiodide, beta-Aminoethylisothiuronium,Diperchlorate, 2-Aminoethylisothiuronium,Diperchlorate, beta-Aminoethylisothiuronium,Hydrobromide, Aminoethylisothiuronium Bromide,Isothiourea, beta-Aminoethyl,Monohydrobromide, 2-Aminoethylisothiuronium,Monohydrobromide, beta-Aminoethylisothiuronium,beta Aminoethyl Isothiourea,beta Aminoethylisothiuronium Bromide,beta Aminoethylisothiuronium Diacetate,beta Aminoethylisothiuronium Dihydrobromide,beta Aminoethylisothiuronium Dihydrochloride,beta Aminoethylisothiuronium Dihydroiodide,beta Aminoethylisothiuronium Diperchlorate,beta Aminoethylisothiuronium Monohydrobromide
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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