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Stationary-phase populations of Chinese hamster V-79 cells were irradiated with 250 kV X-rays and the Bragg peaks (spread to a width of 4 cm) of energetic He-, C-, Ne-, and A-ion beams produced at the 184-inch cyclotron and BEVALAC at Lawrence Berkeley Laboratory. Survival curves were generated with each radiation for cells suspended in air-saturated and nitrogen-saturated medium with and without sensitizer present. The oxygen enhancement ratios (OERs) measured for X-rays with 1mM metronidazole and 0.5 mM misonidazole were 2.0 and 1.6 respectively. The OERs without sensitizer for He-, C-, Ne-, and A-ion Bragg peaks were 2.4, 1.7, 1.6 and 1.4 respectively. For each type of radiation tested the presence of hypoxic-cell sensitizers resulted in an additional reduction in the measured OERs, indicating that these drugs should be of benefit in the radiotherapy planned with these and other high LET radiations.
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
August 1984,
International journal of radiation oncology, biology, physics,
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
June 2011,
Nihon rinsho. Japanese journal of clinical medicine,
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
January 1981,
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J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
September 1966,
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J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
January 2004,
Zeitschrift fur medizinische Physik,
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
January 1978,
International journal of radiation oncology, biology, physics,
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
December 2003,
Gan to kagaku ryoho. Cancer & chemotherapy,
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
April 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
April 1980,
The British journal of radiology,
J D Chapman, and
R C Urtasun, and
E A Blakely, and
K C Smith, and
C A Tobias
January 1982,
International journal of radiation oncology, biology, physics,
