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A pure culture of oligodendrocytes has been developed starting from brain hemispheres of newborn rats. Various effects of acidic and basic fibroblast growth factors (FGFs) on the development of oligodendrocytes have been examined and compared. Both factors elicited similar effects, i.e. stimulation of the proliferation, inhibition of the specific activity of the marker enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase and decrease of the ratio of myelin basic protein positive cells. These results indicate that FGFs are very potent mitogens for oligodendrocytes, even in the absence of other cell types, but that they elicit a negative effect on the cell maturation, possibly related to their strong effect on proliferation.
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
May 1990,
Current eye research,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
January 1989,
Connective tissue research,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
April 1993,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
February 1995,
Neurological research,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
July 1997,
Research communications in molecular pathology and pharmacology,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
July 1997,
Acta oto-laryngologica,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
November 1994,
Brain research. Developmental brain research,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
May 1988,
Journal of neuroscience research,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
October 1997,
Molecular vision,
F Besnard, and
F Perraud, and
M Sensenbrenner, and
G Labourdette
January 1991,
Science (New York, N.Y.),
