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OBJECTIVE This study aimed to investigate the clinical characteristics and prognostic significance of monosomal karyotypes (MKs) in patients with acute myeloid leukemia (AML). METHODS We retrospectively analyzed the clinical data for 498 patients with AML, of whom 233 (46.8%) had an abnormal karyotype, including 42 with MKs (8.4%) and 70 with a complex karyotype (CK) (14.1%). RESULTS Patients with MKs were older (median age 62.5 vs. 52 years, p=0.003) and had lower median hemoglobin levels (62.5 vs. 77 g/L, p=0.009) and lower white blood cell counts (7.0×109/L vs. 11.7×109/L, p=0.008). Univariate analysis showed that patients with MKs or CKs had shorter overall survival than patients without these karyotypes (median survival time 7.3 vs. 26.3 months for MK, p<0.001, and 14.8 vs. 26.3 months for CK, p<0.001). In multivariable analysis for overall survival, MK and National Comprehensive Cancer Network prognostic group were the only significant factors. CONCLUSIONS MK is an independent risk factor for poor prognosis in AML patients.
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
January 2015,
Acta haematologica,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
January 2012,
Asian Pacific journal of cancer prevention : APJCP,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
August 2012,
Oncology (Williston Park, N.Y.),
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
October 2008,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
August 2013,
Leukemia research,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
August 2013,
Leukemia research,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
February 2013,
Leukemia research,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
February 2012,
Leukemia & lymphoma,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
March 2013,
Cancer genetics,
Junqing Xu, and
Baohua Huang, and
Xiaoqian Liu, and
Yuanfeng Zhang, and
Yinghui Liu, and
Liming Chen, and
Yanyan Luan, and
Nannan Li, and
Xiaoxia Chu
January 2015,
Acta haematologica,
