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To elucidate the difference between scirrhous and non-scirrhous gastric carcinomas, we examined the expressions of TGF-beta, procollagen type I and type III in 7 gastric carcinoma cell lines and 37 gastric carcinoma tissues, and also examined the effect of TGF-beta on the expression of procollagen mRNA by TMK-I cells. TGF-beta mRNA was detected in all the tumors examined in vivo and in vitro. Interestingly, 9 (90%) of 10 scirrhous gastric carcinomas revealed higher levels of TGF-beta mRNA than normal tissues, while 8 (38%) of 21 well-differentiated adenocarcinomas had higher TGF-beta mRNA levels than normal tissues. As for procollagen mRNA, most of the human gastric carcinoma cell lines expressed type-I procollagen mRNA and MKN-I expressed type-III procollagen mRNA. Furthermore, procollagen type-I mRNA accumulation in TMK-I cells was increased by exogenous TGF-beta. Most of the tumor tissues from surgical specimens expressed higher procollagen mRNA than normal tissues. These results indicate that TGF-beta produced by carcinoma cells might stimulate collagen synthesis not only by fibroblasts but also by carcinoma cells themselves, leading to diffuse fibrosis of scirrhous gastric carcinomas.
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
July 1999,
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
August 2010,
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI),
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
May 1995,
The American journal of pathology,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
December 1998,
Journal of the American Society of Nephrology : JASN,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
June 1993,
Investigative ophthalmology & visual science,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
February 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
October 1993,
The Journal of laboratory and clinical medicine,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
July 1999,
International journal of oncology,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
February 1994,
Journal of cellular biochemistry,
K Yoshida, and
H Yokozaki, and
M Niimoto, and
H Ito, and
M Ito, and
E Tahara
May 2008,
Carcinogenesis,
