Lumbosacral spinal segmental contributions to tibial and pudendal neuromodulation of bladder overactivity in cats. 2017

Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania.

OBJECTIVE To determine the spinal segmental afferent contributions to tibial and pudendal inhibition of bladder overactivity. METHODS Intravesical infusion of 0.5% acetic acid was used to irritate the bladder and induce bladder overactivity in anesthetized cats. Tibial or pudendal nerve stimulation was used to suppress the bladder overactivity and increase bladder capacity during cystometry. L5-S3 dorsal roots ipsilateral to the stimulation were exposed by a laminectomy and transected sequentially during the experiments to determine the role of individual dorsal roots in tibial or pudendal neuromodulation. RESULTS Transection of L5 dorsal root had no effect. Transection of L6 dorsal root in four cats produced an average 18% reduction in tibial inhibition, which is not a significant change when averaged in the group of 10 cats. Transection of L7 dorsal root completely removed the tibial inhibition without changing reflex bladder activity or pudendal inhibition. Transection of S1 dorsal root reduced the pudendal inhibition, after which transection of S2 dorsal root completely removed the pudendal inhibition. Transection of S3 dorsal root had no effect. The control bladder capacity was increased only by transection of S2 dorsal root. CONCLUSIONS This study in cats revealed that tibial and pudendal neuromodulation of reflex bladder overactivity depends on activation of primary afferent pathways that project into different spinal segments. This difference may be related to the recent observation in cats that the two types of neuromodulation have different mechanisms of action.

UI MeSH Term Description Entries
D008297 Male Males
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013126 Spinal Nerve Roots Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS. Dorsal Roots,Spinal Roots,Ventral Roots,Dorsal Root,Nerve Root, Spinal,Nerve Roots, Spinal,Root, Dorsal,Root, Spinal,Root, Spinal Nerve,Root, Ventral,Roots, Dorsal,Roots, Spinal,Roots, Spinal Nerve,Roots, Ventral,Spinal Nerve Root,Spinal Root,Ventral Root
D013979 Tibial Nerve The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot. Medial Plantar Nerve,Posterior Tibial Nerve,Medial Plantar Nerves,Nerve, Medial Plantar,Nerve, Posterior Tibial,Nerve, Tibial,Nerves, Medial Plantar,Nerves, Posterior Tibial,Nerves, Tibial,Plantar Nerve, Medial,Plantar Nerves, Medial,Posterior Tibial Nerves,Tibial Nerve, Posterior,Tibial Nerves,Tibial Nerves, Posterior
D053201 Urinary Bladder, Overactive Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present. Overactive Detrusor,Bladder, Overactive,Overactive Bladder,Overactive Detrusor Function,Overactive Urinary Bladder,Detrusor Function, Overactive,Detrusor, Overactive
D060525 Pudendal Nerve A nerve which originates in the sacral spinal cord (S2 to S4) and innervates the PERINEUM, the external GENITALIA, the external ANAL SPHINCTER and the external urethral sphincter. It has three major branches: the perineal nerve, inferior anal nerves, and the dorsal nerve of penis or clitoris. Dorsal Clitoris Nerve,Dorsal Nerve of Clitoris,Dorsal Nerve of Penis,Dorsal Penile Nerve,Inferior Anal Nerve,Inferior Hemorrhoidal Nerve,Perineal Nerve,Anal Nerve, Inferior,Anal Nerves, Inferior,Clitoris Dorsal Nerve,Clitoris Dorsal Nerves,Clitoris Nerve, Dorsal,Clitoris Nerves, Dorsal,Dorsal Clitoris Nerves,Dorsal Penile Nerves,Hemorrhoidal Nerve, Inferior,Hemorrhoidal Nerves, Inferior,Inferior Anal Nerves,Inferior Hemorrhoidal Nerves,Nerve, Dorsal Clitoris,Nerve, Dorsal Penile,Nerve, Inferior Anal,Nerve, Inferior Hemorrhoidal,Nerve, Perineal,Nerve, Pudendal,Nerves, Dorsal Clitoris,Nerves, Dorsal Penile,Nerves, Inferior Anal,Nerves, Inferior Hemorrhoidal,Nerves, Perineal,Nerves, Pudendal,Penile Nerve, Dorsal,Penile Nerves, Dorsal,Penis Dorsal Nerve,Penis Dorsal Nerves,Perineal Nerves,Pudendal Nerves
D019342 Acetic Acid Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Glacial Acetic Acid,Vinegar,Acetic Acid Glacial,Acetic Acid, Glacial,Glacial, Acetic Acid

Related Publications

Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
March 2017, American journal of physiology. Renal physiology,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
October 2018, Experimental neurology,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
July 2017, The Journal of pharmacology and experimental therapeutics,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
October 2018, Neuromodulation : journal of the International Neuromodulation Society,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
June 2017, Neurourology and urodynamics,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
June 2012, American journal of physiology. Renal physiology,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
March 2014, The Journal of urology,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
January 2017, Neuromodulation : journal of the International Neuromodulation Society,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
June 2014, The Journal of pharmacology and experimental therapeutics,
Utsav Bansal, and Thomas W Fuller, and Xuewen Jiang, and Jathin Bandari, and Zhaocun Zhang, and Bing Shen, and Jicheng Wang, and James R Roppolo, and William C de Groat, and Changfeng Tai
September 2013, American journal of physiology. Renal physiology,
Copied contents to your clipboard!