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Selective Pinacol-Coupling Reaction using a Continuous Flow System. 2016
Sorbonne Universités, Université de Technologie de Compiègne , Centre de Recherche Royallieu, CS 60 319, F-60203 Compiègne cedex, France.
The first continuous flow pinacol coupling reaction of carbonyl compounds was successfully achieved within only 2 min during a single pass through a cartridge filled with zinc(0). The optimized method allowed the efficient production of gram-scale value-added compounds with high productivity. The developed methodology is efficient for aromatic or α,β-unsaturated aldehydes but gives moderate results for more stable acetophenone derivatives. Moreover, the flow method displayed better results in terms of yield and selectivity in comparison to the corresponding batch methodology.
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