28-day toxicity in beagle dogs of physostigmine salicylate administered via subcutaneously implanted Alzet osmotic minipumps.
1989
D W Korte, and
D F Frost, and
G M Zaucha, and
P P Waring, and
C B Clifford, and
C R Wheeler
Division of Toxicology, Letterman Army Institute of Research, Presidio of San Francisco, California 94129-6800.
UI
MeSH Term
Description
Entries
D010830
Physostigmine
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Eserine
D004285
Dogs
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Canis familiaris,Dog
D004343
Drug Implants
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Drug Implant,Drug Pellet,Pellets, Drug,Drug Pellets,Implant, Drug,Implants, Drug,Pellet, Drug
D000818
Animals
Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.
Animal,Metazoa,Animalia
D013997
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Time Series,Factor, Time,Time Factor
Related Publications
D W Korte, and
D F Frost, and
G M Zaucha, and
P P Waring, and
C B Clifford, and
C R Wheeler