-transparent.png){kind=logo}
Antipyrine metabolism was determined after hemodilution with 40 ml/kg of Fluosol in conscious, unrestrained female and male rats. Rats received an intravenous antipyrine dose (20 mg/kg) 24, 48, or 72 hours after hemodilution and the pharmacokinetic parameters were compared to non-exchanged control animals. Changes in the plasma disposition parameters were the same in both genders but the specific characteristic of a greater half-life in female rats was retained. A significant increase in antipyrine clearance was found at 48 hours after hemodilution. 3OHME clearance was increased in both female and male rats but 4OH clearance was increased only in female rats at that time. The data also suggested that the Fluosol emulsion induced a different microsomal enzyme activity change than its most studied component, perfluorodecalin.
R P Shrewsbury, and
L G White
January 1992,
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology,
R P Shrewsbury, and
L G White
March 1987,
Research communications in chemical pathology and pharmacology,
R P Shrewsbury, and
L G White
July 1981,
Masui. The Japanese journal of anesthesiology,
R P Shrewsbury, and
L G White
January 1989,
Advances in experimental medicine and biology,
R P Shrewsbury, and
L G White
July 1983,
Clinical chemistry,
R P Shrewsbury, and
L G White
January 1983,
Progress in clinical and biological research,
R P Shrewsbury, and
L G White
January 1983,
Progress in clinical and biological research,
R P Shrewsbury, and
L G White
September 1986,
The Journal of pharmacy and pharmacology,
R P Shrewsbury, and
L G White
January 1981,
Bibliotheca haematologica,
R P Shrewsbury, and
L G White
April 1985,
Anesthesia and analgesia,
