BIOMAT Database Logo BIOMAT Database Logo

The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance. 2017

N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan.

The purpose of this study was to investigate the effects of the MCT1 T1470A polymorphism (rs1049434) on power-oriented performance and lactate concentration during or after cycling sprints in Japanese wrestlers. Participants (199 wrestlers and 649 controls) were genotyped for the MCT1 T1470A genotype (rs1049434) using the TaqMan® Assay. All wrestlers were international (n=77) or national (n=122) level athletes. Among them, 46 wrestlers performed 2 anaerobic performance tests, a 30-s Wingate Anaerobic test (WAnT) and a series of 10 maximal effort 10-s sprints on a cycle ergometer. Blood lactate levels were measured before, during, and after the tests. In the A-allele recessive model (AA vs. TA+TT), the frequency of the AA genotype was significantly higher in all wrestlers than in controls (p=0.037). Wrestlers with AA genotype had lower blood lactate concentrations than those with TA+TT genotype at 10 min after the WAnT and following the 5th and the final set of repeated cycling sprints (p<0.05). The AA genotype of the MCT1 T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s WAnT and during intermittent sprint tests in Japanese wrestlers.

UI MeSH Term Description Entries
D007564 Japan A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo. Bonin Islands
D008297 Male Males
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014952 Wrestling A sport consisting of hand-to-hand combat between two unarmed contestants seeking to pin or press each other's shoulders to the ground. Wrestlings
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control
D044466 Asian People Persons having origins in any of the Asian racial groups of the Far East, Southeast Asia, or the Indian subcontinent including, for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. Note that OMB category ASIAN is available for United States population groups. Race and ethnicity terms, as used in the federal government, are self-identified social construct and may include terms outdated and offensive in MeSH to assist users who are interested in retrieving comprehensive search results for studies such as in longitudinal studies. Asian Continental Ancestry Group,Asian Person,Asiatic Race,Mongoloid Race,Asian Peoples,Asian Persons,Asiatic Races,Mongoloid Races,People, Asian,Person, Asian,Race, Asiatic,Race, Mongoloid

Related Publications

N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers.
June 2021, Biology of sport,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
A common polymorphism of the MCT1 gene and athletic performance.
January 2014, International journal of sports physiology and performance,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
The Association between the ALDH2 rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes.
September 2022, Genes,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance.
December 2019, Biology of sport,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Can IGF-I polymorphism affect power and endurance athletic performance?
October 2013, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women.
November 2012, Journal of science and medicine in sport,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Power laws and athletic performance.
June 1999, Journal of sports sciences,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Is there an association between ACTN3 R577X polymorphism and muscle power phenotypes in young, non-athletic adults?
October 2010, Scandinavian journal of medicine & science in sports,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
Influence of the MCT1-T1470A polymorphism (rs1049434) on repeated sprint ability and blood lactate accumulation in elite football players: a pilot study.
December 2021, European journal of applied physiology,
N Kikuchi, and N Fuku, and R Matsumoto, and S Matsumoto, and H Murakami, and M Miyachi, and K Nakazato
MCT1 A1470T: a novel polymorphism for sprint performance?
January 2015, Journal of science and medicine in sport,
Copied contents to your clipboard!