The author reports on his experience in the treatment of urethral stenosis using lyophilized human dura mater for urethral augmentation and replacement. The excellent results achieved in experiments using lyophilized human dura mater as a homoplastic material for tissue augmentation and replacement has led to its use in clinical application. The results achieved utilizing this material in the treatment of 20 patients with urethral stenosis further corroborate its usefulness as an alloplastic material, and as an alternative to autologous grafts.