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Polyclonal B cell activation is commonly observed in AIDS and in infection with HIV. The effect of HIV on the induction of B cell stimulatory factor 2 (BSF-2) production was examined, since BSF-2 plays an essential role in the differentiation of activated B cells to Ig-secreting cells. Increased BSF-2 mRNA levels and increased BSF-2 secretion were observed soon after exposure of mononuclear cells isolated from healthy donors to both "live" and inactivated HIV. HIV-induced BSF-2 production was seen in monocyte/macrophages, but not in T cells. These results suggest that the HIV-induced overproduction of BSF-2 might contribute to the polyclonal B cell activation seen in AIDS and in infection with HIV.
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
January 1989,
Journal of biological regulators and homeostatic agents,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
June 1988,
Journal of immunology (Baltimore, Md. : 1950),
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
January 1989,
Annals of the New York Academy of Sciences,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
June 1988,
Biochemical and biophysical research communications,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
August 1988,
Molecular and cellular biology,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
October 1987,
The EMBO journal,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
November 1988,
European journal of immunology,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
August 1989,
Clinical immunology and immunopathology,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
February 1989,
FEBS letters,
K Nakajima, and
O Martínez-Maza, and
T Hirano, and
E C Breen, and
P G Nishanian, and
J F Salazar-Gonzalez, and
J L Fahey, and
T Kishimoto
June 1988,
European journal of immunology,
