Self-Consciousness Deficits in Alzheimer's Disease and Frontotemporal Dementia. 2017

Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
Department of Psychobiology, Neuroscience Institute of Castilla-León, University of Salamanca, Salamanca, Spain.

Self-consciousness (SC) is multifaceted and considered to be the consciousness of one's own mental states. The main aim of this paper is to compare SC in patients with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). Three groups (control and patient groups) of 23 subjects each were assessed using an SC questionnaire. Both types of dementia clearly induce an alteration of SC. The bvFTD group showed a greater impairment in SC than the AD and control groups. The SC score was strongly associated with frontal functions. The most significantly impaired SC aspects in the bvFTD group were Anosognosia, Introspection, and Moral Judgments. For the AD group, the significantly impaired aspects of SC were Anosognosia and Prospective Memory. The differences in SC between the AD and bvFTD groups were essentially centered on the Anosognosia, Moral Judgments, and Introspection aspects, which were highly impaired in the bvFTD patients. This suggests that SC is related to orbito-frontal functioning and thus, to the default mode network.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D003244 Consciousness Disorders Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition. Consciousness, Level Altered,Disorder of Consciousness,Disorders of Consciousness,Semiconsciousness,Altered Level of Consciousness,Consciousness, Level Depressed,Depressed Level of Consciousness,Consciousness Disorder
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses

Related Publications

Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
September 2004, Psychologie & neuropsychiatrie du vieillissement,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
September 2007, Journal of neurology, neurosurgery, and psychiatry,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
January 2007, Dialogues in clinical neuroscience,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
March 2010, Journal of clinical and experimental neuropsychology,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
June 2001, Acta neurologica Scandinavica,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
June 2008, Brain and cognition,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
January 2007, Neuropsychology,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
November 2001, Acta neurologica Scandinavica,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
October 2012, Brain : a journal of neurology,
Eva Ma Arroyo-Anlló, and Adèle Turpin Bouston, and Marie-Noëlle Fargeau, and Begoña Orgaz Baz, and Roger Gil
January 1999, Dementia and geriatric cognitive disorders,
Copied contents to your clipboard!