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We examined the behaviour of [3H]inositol-1,4,5-trisphosphate (IP3) binding in autopsied cerebellar and cerebral cortex of 10 neurologically normal controls and 8 patients with end-stage olivopontocerebellar atrophy (OPCA), a cerebellar ataxia disorder characterized histologically by severe degeneration of Purkinje cells. [3H]IP3 binding to normal human cerebellar cortex was 6-15 times higher than in cerebral cortex. As compared with the controls, mean [3H]IP3 binding to cerebellar cortex was markedly reduced by 61% in the OPCA patients whereas levels were normal in frontal and occipital cortices. Since the Purkinje cell dendrite receives neuronal input from granule cells and climbing fibers utilizing glutamate and aspartate, respectively, as neurotransmitters, the reduced IP3 binding in OPCA cerebellar cortex may reflect a loss of Purkinje cells containing these excitatory amino acid receptors linked to the phosphatidylinositide second messenger system. Our data suggest that in humans, IP3 receptors may be highly localized to the Purkinje cell dendrite.
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
June 1991,
Brain research,
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
October 1988,
The Biochemical journal,
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
January 1994,
Neurochemistry international,
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
January 1997,
Journal of neural transmission (Vienna, Austria : 1996),
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
December 1987,
Life sciences,
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
September 1996,
Alcohol and alcoholism (Oxford, Oxfordshire),
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
July 1998,
Psychopharmacology,
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
July 1992,
Journal of the neurological sciences,
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
November 1996,
Biological psychiatry,
S J Kish, and
P P Li, and
Y Robitaille, and
R Currier, and
J Gilbert, and
L Schut, and
J J Warsh
November 1991,
Neuroscience letters,
