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Blastogenic responses of human lymphocytes to a streptococcal preparation OK-432 and its fractions. 1989
T Tanaka, and
Y Kaneko, and
F Haba, and
S Katsuta, and
K Tsutsui, and
S Tamaki, and
D R Chen, and
S Suzuki, and
R Ueda, and
A Yamamoto
3rd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
This study was undertaken to examine the blastogenic responses of PBL to Streptococcal preparation OK-432 and its fractions. The results showed that OK-432 and its fractions, Su-PR and PM, have the mitogenic activity against human lymphocytes. The demonstration that PBL which had been cultured with OK-432 expressed IL-2 receptors and the blastogenic responses of PBL to OK-432 were inhibited by anti-IL-2 antibody suggested that IL-2 and IL-2 receptors might play a central role in OK-432-induced proliferation of human lymphocytes.
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Nihon Geka Gakkai zasshi,
