Biomaterial Database

Pharmacotherapy of masticatory system dysfunction. 1978

R G Jagger

The decision to use drugs systemically in the management of mandibular dysfunction must be made with consideration of the information summarized in this report. It has been shown that pharmacotherapy may be effective. It has also been demonstrated that systemic pharmacotherapy frequently produces side effects which are occasionally severe. The clinician must decide on the appropriateness of therapy with the knowledge that many other conservative measures may also have excellent success rates and that pharmacotherapy is likely to be palliative rather than curative.

UI	MeSH Term	Description	Entries
D008409	Mastication	The act and process of chewing and grinding food in the mouth.	Chewing
D008620	Meprobamate	A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)	Dapaz,Equanil,Meprospan,Miltown,Méprobamate Richard,Tranmep,Visano
D009966	Orphenadrine	A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.	Methyldiphenylhydramine,Disipal,Lysantin,Mefenamine,Mephenamine,Norflex,Norflex Orphenadrine Citrate,Orphenadrine Citrate,Orphenadrine Hydrochloride,Sodium Mefenamine,Citrate, Norflex Orphenadrine,Citrate, Orphenadrine,Hydrochloride, Orphenadrine,Mefenamine, Sodium,Orphenadrine Citrate, Norflex
D010919	Placebos	Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.	Sham Treatment
D003975	Diazepam	A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.	7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one,Apaurin,Diazemuls,Faustan,Relanium,Seduxen,Sibazon,Stesolid,Valium
D005018	Ethyl Chloride	A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine.	Chloroethane,Chloraethyl Dr. Henning,Cloretilo Chemirosa,Gebauer's Ethyl Chloride,WariActiv,Chemirosa, Cloretilo,Chloride, Ethyl,Gebauer Ethyl Chloride,Gebauers Ethyl Chloride
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000772	Anesthesia, Local	A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.	Anesthesia, Infiltration,Local Anesthesia,Neural Therapy of Huneke,Huneke Neural Therapy,Infiltration Anesthesia
D000928	Antidepressive Agents	Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.	Antidepressant,Antidepressant Drug,Antidepressant Medication,Antidepressants,Antidepressive Agent,Thymoanaleptic,Thymoanaleptics,Thymoleptic,Thymoleptics,Antidepressant Drugs,Agent, Antidepressive,Drug, Antidepressant,Medication, Antidepressant
D013706	Temporomandibular Joint Dysfunction Syndrome	A symptom complex consisting of pain, muscle tenderness, clicking in the joint, and limitation or alteration of mandibular movement. The symptoms are subjective and manifested primarily in the masticatory muscles rather than the temporomandibular joint itself. Etiologic factors are uncertain but include occlusal dysharmony and psychophysiologic factors.	Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint,TMJ Syndrome,Temporomandibular Joint Syndrome,Costen's Syndrome,Costen Syndrome,Costens Syndrome,Joint Syndrome, Temporomandibular,Syndrome, Costen's,Syndrome, TMJ,Syndrome, Temporomandibular Joint