A plasmacytic lymphoma of the cervical nodes in a 71-year-old women spread also to the mediastinal nodes and after two years proved fatal. The authors did not detect a rise of monoclonal serum immunoglobulins nor did they detect their presence in the cytoplasm of tumour cells in the nodes subjected to biopsy. The lymphoma was preceded by a specific granulomatous inflammation of the skin and nodes persisting for four years.