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Long-term results in the treatment of 116 patients of acute lymphocitic leukemia with ages between six months and seven years are reported. A first group A, formed by 76 patients, was treated with prednisone and vincristine as induction protocol and maintenance therapy with 6-mercaptopurine or methotrexate. No neuromeningeal prophylaxis was made, except some cases in which intratecal methotrexate was applied. 27 patients are alive, 21 of them (27,6%) remain in complete remission for more than three years. A second group B, formed by 40 patients, was treated more recently; with an induction protocol composed by prednisone, vincristine and L-asparaginase. All patients in this group received cranial irradiation and intratecal methotrexate. 31 patients are alive (77,5%), 13 of them (32,5%) remain in complete remission for more than two years. The evolution period in this group B is shorter, but some features are exposed which suggest the possibility of long-term better results.
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
June 1980,
Blut,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
January 1979,
Klinische Padiatrie,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
August 1977,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
March 1975,
Orvosi hetilap,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
July 1974,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
January 1979,
Medical and pediatric oncology,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
December 1981,
Cancer,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
January 1988,
Archiv fur Geschwulstforschung,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
June 1987,
Seminars in oncology,
M C González-Martín, and
A Muñóz Villa, and
P García-Miguel, and
A Herrero Díez, and
T Hurtado Ruano, and
J L Fernández Epifanio
December 1977,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
