-transparent.png){kind=logo}
A factor which may induce differentiation of intestinal epithelial cell lines in vitro was found in an acid extract of adult rat small intestine. The addition of a partially purified acetic acid extract of rat small intestine to IEC-18 cell culture dishes increased sucrase activity within 48 h. Thymidine incorporation markedly decreased within 24 h. Significant development of microvilli-like structures was observed on the acid extract-treated IEC-18 cells, compared with controls. This activity of rat acid extract was heat-stable and the apparent molecular weight of the factor was 400-800. These findings suggested that the factor may be related to the epithelial differentiation of rat small intestinal crypt cells.
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
August 1992,
The Journal of laboratory and clinical medicine,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
January 2005,
Journal of cellular physiology,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
June 1991,
Gastroenterology,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
March 1996,
In vitro cellular & developmental biology. Animal,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
January 1987,
Endocrine research,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
April 1991,
Experimental cell research,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
May 1994,
The American journal of physiology,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
January 2018,
Frontiers in pharmacology,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
January 2003,
In vitro cellular & developmental biology. Animal,
T Shintani, and
T Fushiki, and
S Fukuoka, and
H Takahashi-Iwanaga, and
E Sugimoto
October 1995,
Experimental cell research,
