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The compound 4'-(9-acridinylamino)methanesulfon-m-anisidide is a new derivative that was evaluated in a Phase 1 clinical trial. The schedule of drug administration consisted of daily i.v. injection for 3 consecutive days, repeated at 3-week intervals. Twenty-six patients received a total of 63 courses of 4'-(9-acridinylamino)methanesulfon-m-anisidide in a dose range from 4 to 50 mg/sq m/day. Hematopoietic toxicity was dose limiting, but it was of short duration and rapidly reversible. Mild nausea and vomiting were observed in 16% of the courses, and a mild degree of phlebitis was observed in 10% of the courses. Responses were observed in two patients with adenocarcinoma of the lung and one each of melanoma and acute myeloblastic leukemia. Phase 2 studies of 4'-(9-acridinylamino)methanesulfon-m-anisidide are planned at a starting dose of 40 mg/sq m/day for 3 days in good-risk patients and at 25 to 30 mg/sq m/day for 3 days in poor-risk patients. Course of treatment would be repeated at 21-day intervals.
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
January 1980,
Cancer clinical trials,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
April 1982,
Cancer research,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
January 1984,
Cancer chemotherapy and pharmacology,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
February 1983,
American journal of clinical oncology,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
February 1982,
Gan to kagaku ryoho. Cancer & chemotherapy,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
July 1979,
Analytical biochemistry,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
May 1984,
Cancer research,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
January 1979,
Cancer treatment reports,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
November 1980,
Cancer research,
S S Legha, and
J U Gutterman, and
S W Hall, and
R S Benjamin, and
M A Burgess, and
M Valdivieso, and
G P Bodey
June 1982,
American journal of clinical oncology,
