Biomaterial Database

[Pharmacokinetic evaluations and analysis of aztreonam in children]. 1989

H Kawasaki

Department of Pediatrics, Touhoku Rohsai Hospital.

Aztreonam (AZT), monocyclic beta-lactam antimicrobial agent, was administered to 9 children at a dose level of 30 mg/kg through intravenous drip infusion for half-hour. Using serum levels of the drug obtained in blood samples, pharmacokinetic parameters were calculated and a simulation curve of serum levels was drawn automatically using a micro-computer. The mean values (n = 9) for elimination constant (Kel) and half-life (T 1/2) were 0.67 hr-1 and 1.08 hours, respectively. The mean apparent volume of distribution was 4.29 L, and serum clearance was 0.17 L/kg/hr. A basic analysis for the efficacy dose of AZT was performed using above mentioned parameters.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007262	Infusions, Intravenous	The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.	Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age