BIOMAT Database Logo BIOMAT Database Logo

Palladium-Catalyzed Tandem C-H Functionalization/Cyclization Strategy for the Synthesis of 5-Hydroxybenzofuran Derivatives. 2017

Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Department of Chemistry, National Taiwan Normal University , 88, Section 4, Ting-Chow Road, Taipei 116, Taiwan, R.O.C.

A palladium-catalyzed benzoquinone C-H functionalization/cyclization strategy with terminal alkynes was employed for the synthesis of some biologically relevant 2,3-disubstituted 5-hydroxybenzofuran derivatives. The benzoquinone acts as a reactant as well as an oxidant. During the process, an additional alkyne functionality can be introduced at the C3 position of the benzofuran. Base, ligand, and external oxidant are not required in this protocol.

UI MeSH Term Description Entries

Related Publications

Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium(II)-catalyzed tandem cyclization/C-H functionalization of alkynes for the synthesis of functionalized indoles.
October 2012, The Journal of organic chemistry,
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-catalyzed tandem cyclization of bromoenynes through aromatic C-H bond functionalization.
August 2005, Angewandte Chemie (International ed. in English),
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-catalyzed dehydrogenative C-H cyclization for isoindolinone synthesis.
August 2021, RSC advances,
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-Catalyzed C-H Functionalization of Aromatic Oximes: A Strategy for the Synthesis of Isoquinolines.
February 2016, The Journal of organic chemistry,
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation.
October 2008, The Journal of organic chemistry,
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-catalyzed synthesis of cyclopentane-fused benzocyclobutenes via tandem directed carbopalladation/C-H bond functionalization.
August 2007, Organic letters,
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Two-in-One Strategy for Palladium-Catalyzed C-H Functionalization in Water.
February 2019, Angewandte Chemie (International ed. in English),
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives.
October 2021, Organic letters,
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-catalyzed C-H functionalization of acyldiazomethane and tandem cross-coupling reactions.
April 2015, Journal of the American Chemical Society,
Sachin S Ichake, and Ashok Konala, and Veerababurao Kavala, and Chun-Wei Kuo, and Ching-Fa Yao
Palladium-Catalyzed Tandem Nucleophilic Addition/C-H Functionalization of Anilines and Bromoalkynes for the Synthesis of 2-Phenylindoles.
March 2023, Organic letters,
Copied contents to your clipboard!