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A new scintigraphic method to detect myocardial necrosis has been developed using antimyosin monoclonal antibody F ab labeled with indium-111 (111In-antimyosin). We investigated 111In-antimyosin scintigraphy in 35 patients with myocardial infarction, 5 patients with myocarditis and 3 patients with angina pectoris. 111In-antimyosin F ab was administered iv and antimyosin images were recorded by planar and single photon emission computed tomography (SPECT) 48-72 hrs after injection. Planar images showed discrete localization of 111In-antimyosin in 26 of 27 patients within 16 days after the onset of acute myocardial infarction in 14 of whom creatine kinase, glutamic oxaloacetic transaminase and lactic dehydrogenase had already normalized. In addition, positive scans were also obtained in 4 of 8 patients 1 to 9 months after the onset of the disease. Three patients with acute myocarditis (two of whom were biopsy-proven) had positive scans 2 and 4 weeks after the onset of the disease. Although mechanism of persistent positive anti-myosin images in the chronic stage remains to be clarified, 111In-antimyosin scintigraphy holds potential promise as a noninvasive method for the detection of myocardial injury.
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
January 1992,
International journal of cardiac imaging,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
October 1990,
Nuclear medicine communications,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
June 1990,
Kaku igaku. The Japanese journal of nuclear medicine,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
December 1991,
American heart journal,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
January 1993,
Journal of cardiology,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
January 1989,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
January 1991,
Nihon rinsho. Japanese journal of clinical medicine,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
October 1992,
Nuklearmedizin. Nuclear medicine,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
September 1987,
The American journal of cardiology,
A Matsumori, and
T Yamada, and
N Tamaki, and
I Okada, and
M Tominaga, and
C Kawai, and
Y Watanabe, and
Y Yonekura, and
K Endo, and
J Konishi
December 1990,
Kaku igaku. The Japanese journal of nuclear medicine,
