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Murine transforming growth factor-beta 2 (TGF-beta 2) cDNAs were isolated from cDNA libraries derived from a differentiated murine embryonic carcinoma cell line, PCC3. The composite cDNA sequence is 4267 nucleotides long, including a 1217 nucleotides 5'-untranslated sequence, and encodes a murine TGF-beta 2 precursor of 414 amino acids with 96% identity to its human counterpart. Several consensus polyadenylation sequences are present in the 1807 nucleotides 3'-untranslated sequence. Five TGF-beta 2 mRNA species are observed in the developing mouse fetus and they show different patterns of expression during development. TGF-beta 2 mRNA expression was also examined in adult mouse tissues, in which four of the five RNA species were observed. TGF-beta 2 mRNAs were present in all adult mouse tissues examined, except liver, and was most abundant in placenta, the male submaxillary gland and lung. The patterns of expression suggest a physiological role for TGF-beta 2 both in embryonic development and in the maintenance of adult tissues.
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A Lee, and
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E Y Chen, and
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R Derynck
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D A Miller, and
A Lee, and
R W Pelton, and
E Y Chen, and
H L Moses, and
R Derynck
June 1987,
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D A Miller, and
A Lee, and
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R Derynck
August 1989,
Development (Cambridge, England),
D A Miller, and
A Lee, and
R W Pelton, and
E Y Chen, and
H L Moses, and
R Derynck
January 2003,
Journal of molecular medicine (Berlin, Germany),
D A Miller, and
A Lee, and
R W Pelton, and
E Y Chen, and
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R Derynck
January 2000,
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao,
D A Miller, and
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R Derynck
December 1991,
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D A Miller, and
A Lee, and
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R Derynck
February 1991,
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research,
D A Miller, and
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February 1989,
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D A Miller, and
A Lee, and
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R Derynck
November 2003,
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D A Miller, and
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E Y Chen, and
H L Moses, and
R Derynck
June 2005,
Differentiation; research in biological diversity,
