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Since the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVMAC), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.
H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
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H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
January 2005,
Journal of virology,
H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
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H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
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Virology,
H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
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Journal of virology,
H Tsujimoto, and
A Hasegawa, and
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M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
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Microbes and infection,
H Tsujimoto, and
A Hasegawa, and
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M Fukasawa, and
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S Speidel, and
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E N Moriyama, and
T Gojobori, and
M Hayami
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Journal of virology,
H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
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E N Moriyama, and
T Gojobori, and
M Hayami
April 2003,
Journal of virology,
H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
June 2003,
Journal of virology,
H Tsujimoto, and
A Hasegawa, and
N Maki, and
M Fukasawa, and
T Miura, and
S Speidel, and
R W Cooper, and
E N Moriyama, and
T Gojobori, and
M Hayami
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