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The effect of food on the bioavailability of a nifedipine sustained-release preparation was studied. Each of seven male volunteers received a single oral 20 mg dose with 100 mL of water under two conditions, fasting and after a meal, with a crossover after a seven-day wash-out period. Blood samples were drawn at time zero (just prior to dose), and 1, 2, 3, 4, 6, 8, 10, and 12 hours after dosing. Nifedipine assays were performed by gas chromatography. The area under the serum concentration-time curve (AUC) from 0 to 12 hours and maximum serum concentration (Cmax) were significantly increased by food. Blood pressure was significantly decreased by food. The mean AUC for fasting and meal conditions were 315.0 and 411.4 ng.h/mL, and the mean Cmax were 42.6 and 86.6 micrograms/mL, respectively. The results indicate that food may increase the bioavailability of nifedipine sustained-release preparation.
K Ueno, and
S Kawashima, and
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K Yamazaki, and
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I Nakata
June 2000,
Drug development and industrial pharmacy,
K Ueno, and
S Kawashima, and
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T Ikada, and
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K Yamazaki, and
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I Nakata
January 1996,
Yao xue xue bao = Acta pharmaceutica Sinica,
K Ueno, and
S Kawashima, and
K Uemoto, and
T Ikada, and
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K Wada, and
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I Nakata
September 1985,
Chemical & pharmaceutical bulletin,
K Ueno, and
S Kawashima, and
K Uemoto, and
T Ikada, and
K Miyai, and
K Wada, and
K Yamazaki, and
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I Nakata
January 1986,
Journal of pharmaceutical sciences,
K Ueno, and
S Kawashima, and
K Uemoto, and
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K Wada, and
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I Nakata
April 1984,
The Medical journal of Australia,
K Ueno, and
S Kawashima, and
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I Nakata
March 1990,
Journal of pharmaceutical sciences,
K Ueno, and
S Kawashima, and
K Uemoto, and
T Ikada, and
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I Nakata
December 1996,
Internal medicine (Tokyo, Japan),
K Ueno, and
S Kawashima, and
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I Nakata
January 1971,
Scandinavian journal of haematology,
K Ueno, and
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T Ikada, and
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K Matsumoto, and
I Nakata
January 1983,
Drug intelligence & clinical pharmacy,
K Ueno, and
S Kawashima, and
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T Ikada, and
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K Yamazaki, and
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I Nakata
July 1987,
Clinical pharmacology and therapeutics,
