-transparent.png){kind=logo}
To assess the value of subrenal capsule assay (SRCA) for predictive chemo-sensitivity testing in breast cancer 24 primary tumours were examined in normal immunocompetent (NIC; AB- and B6D2-F1-) mice. In 6 cancers the effect of 0.25 mg Prednisolone mous X day (applicated with drinking water) was compared to the control group. Independent of the mice-species a significant increase of the grafts size occurred in 14 of 20 evaluable cancers (p less than 0.05). Histologically the increase of tumour size was caused by infiltrated host cells, only in 22 of 107 (20.6%) grafts vitale tumour cells were detectable. After immunosuppression the increase of the grafts size was significant lower, than in the no treated control group (p less than 0.05). In groups treated with Prednisolone only a thin inflammatory host cell infiltration was observed, but vital tumour cells were only seen in 3 of 29 (10.3%) grafts. CONCLUSIONS Using normal immunocompetent mice subrenal capsule assay is not suited for predicting responsiveness of breast cancers to cytostatic drugs.
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
September 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
September 1986,
European journal of cancer & clinical oncology,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
January 1988,
Progress in clinical and biological research,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
March 1990,
Gan to kagaku ryoho. Cancer & chemotherapy,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
February 1990,
Japanese journal of cancer research : Gann,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
August 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
January 1985,
Annales chirurgiae et gynaecologiae. Supplementum,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
January 1985,
Annales chirurgiae et gynaecologiae. Supplementum,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
January 1985,
Annales chirurgiae et gynaecologiae. Supplementum,
B Gerber, and
D Richter, and
E Rohde, and
H Wilken, and
K Rudolf, and
R Kasch
August 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
