-transparent.png){kind=logo}
Osteogenic disorder syndrome rats are unable to synthesize ascorbic acid owing to the lack of l-gulonolactone oxidase, and become scorbutic within a few weeks without the supply of ascorbic acid. We studied effects of ascorbic acid deficiency on the ovarian aromatase activity in vivo using osteogenic disorder syndrome rats. The ovarian aromatase activity in ascorbic acid-deficient osteogenic disorder syndrome rats was significantly higher than that in normal or ascorbic acid-supplied osteogenic disorder syndrome rats. The activity in hypophysectomized immature rats was extremely low, but increased after treatment with pregnant mare serum gonadotropin, regardless of the presence or absence of ascorbic acid. The extent of the increase was the same among experimental groups. The present results indicate that ascorbic acid at physiological level lowers the ovarian aromatase activity, whereas it does not impair the responsiveness of the aromatase activity to gonadotropins.
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
January 1990,
Life sciences,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
September 1990,
The Journal of steroid biochemistry and molecular biology,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
December 1985,
The Journal of nutrition,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
January 1996,
Archives of toxicology,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
February 1991,
Journal of nutritional science and vitaminology,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
June 2006,
Anatomical science international,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
February 2003,
Life sciences,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
January 2000,
Proceedings of the National Academy of Sciences of the United States of America,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
November 1986,
The Journal of nutrition,
M Tsuji, and
Y Ito, and
N Terada, and
H Mori
April 1997,
European journal of biochemistry,
