BIOMAT Database Logo BIOMAT Database Logo

Autoimmunity in Primary Antibody Deficiencies. 2016

Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.

Primary antibody deficiencies (PADs) are the most common inherited primary immunodeficiencies in humans, characterized by hypogammaglobulinemia, an inability to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimmunity are associated with the various types of PAD. Both systemic and organ-specific autoimmune diseases could be attributed to B-cell defects in PAD patients. Immune thrombocytopenic purpura and autoimmune hemolytic anemia are the most common autoimmune disorders in this group of patients. The aim of this review is to describe the proposed mechanisms for autoimmunity and to review the literature with respect to the reported autoimmune disorders in each type of PAD.

UI MeSH Term Description Entries
D007108 Immune Tolerance The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. Immunosuppression (Physiology),Immunosuppressions (Physiology),Tolerance, Immune
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000361 Agammaglobulinemia An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood. Hypogammaglobulinemia,Agammaglobulinemias,Hypogammaglobulinemias
D000906 Antibodies Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D001327 Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune
D015551 Autoimmunity Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES. Autoimmune Response,Autoimmune Responses,Autoimmunities

Related Publications

Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Autoimmunity in a cohort of 471 patients with primary antibody deficiencies.
November 2017, Expert review of clinical immunology,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Primary Antibody Deficiencies.
January 2020, Advances in experimental medicine and biology,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Primary antibody deficiencies.
July 2013, Nature reviews. Immunology,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
[Autoimmune disease in primary antibody deficiencies].
January 2005, Allergologia et immunopathologia,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Lung Disease in Primary Antibody Deficiencies.
January 2016, The journal of allergy and clinical immunology. In practice,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
[Primary and secondary antibody deficiencies].
September 1984, La Clinica terapeutica,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Children and primary antibody deficiencies.
January 1994, Nursing standard (Royal College of Nursing (Great Britain) : 1987),
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Educational paper: primary antibody deficiencies.
June 2011, European journal of pediatrics,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
[Primary deficiencies in antibody synthesis. II. Dysgammaglobulinemias].
May 1983, Boletin medico del Hospital Infantil de Mexico,
Gholamreza Azizi, and Moslem Ahmadi, and Hassan Abolhassani, and Reza Yazdani, and Hamed Mohammadi, and Abbas Mirshafiey, and Nima Rezaei, and Asghar Aghamohammadi
Update on Infections in Primary Antibody Deficiencies.
January 2021, Frontiers in immunology,
Copied contents to your clipboard!