-transparent.png){kind=logo}
The antiviral effect of 9-MS was examined in mice infected with mouse-adapted influenza A2 (H2N2) virus. Either a single or a continuous prophylactic administration of 9-MS protected mice from virus infection, and comparison of the minimal effective dose with the lethal dose gave a therapeutic index of approximately 60. When the treatment was started after infection, however, no antiviral effect was demonstrated. A potent virus-inhibitory factor was detected in the lung and serum after a single intraperitoneal administration of 9-MS in uninfected mice, and on the basis of chemical characteristics of this inhibitory factor, it was assumed to be an interferon. These results suggest that the protective activity of the antibiotic in mice is due to interferon induction.
F Suzuki, and
N Saito, and
N Ishida
June 1978,
Antimicrobial agents and chemotherapy,
F Suzuki, and
N Saito, and
N Ishida
September 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
F Suzuki, and
N Saito, and
N Ishida
January 1969,
Bulletin of the World Health Organization,
F Suzuki, and
N Saito, and
N Ishida
March 1983,
Antiviral research,
F Suzuki, and
N Saito, and
N Ishida
January 1983,
Voprosy virusologii,
F Suzuki, and
N Saito, and
N Ishida
June 1980,
Biken journal,
F Suzuki, and
N Saito, and
N Ishida
April 1978,
Infection and immunity,
F Suzuki, and
N Saito, and
N Ishida
January 1972,
Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology,
F Suzuki, and
N Saito, and
N Ishida
December 1973,
Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology,
F Suzuki, and
N Saito, and
N Ishida
January 1981,
Voprosy virusologii,
