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The kinetics of prostaglandins instilled vaginally has been studied in the maternal and fetal circulations, with observation of changes in the stable prostaglandin E2 metabolite 11-deoxy-13,14-dihydro-15-keto-11 beta,16-cyclo-prostaglandin E2. After the administration of prostaglandin E2, 10 mg in a wax-based pessary, concentrations of prostaglandin E2 metabolite in the maternal circulation increased; concentrations in the fetal circulation were higher than those in control subjects. There was a positive correlation between levels found in the fetal and maternal circulations. The implications of these preliminary findings are discussed in relation to the consequences of the use of vaginally administered prostaglandin E2 for cervical ripening and labor induction.
I Z MacKenzie, and
B Castle, and
J Bellinger
October 1980,
British medical journal,
I Z MacKenzie, and
B Castle, and
J Bellinger
September 1990,
Lancet (London, England),
I Z MacKenzie, and
B Castle, and
J Bellinger
June 1980,
Obstetrics and gynecology,
I Z MacKenzie, and
B Castle, and
J Bellinger
September 1990,
Lancet (London, England),
I Z MacKenzie, and
B Castle, and
J Bellinger
January 2002,
The Central African journal of medicine,
I Z MacKenzie, and
B Castle, and
J Bellinger
November 1991,
British journal of clinical pharmacology,
I Z MacKenzie, and
B Castle, and
J Bellinger
May 2005,
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
I Z MacKenzie, and
B Castle, and
J Bellinger
March 1992,
American journal of obstetrics and gynecology,
I Z MacKenzie, and
B Castle, and
J Bellinger
September 2003,
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians,
I Z MacKenzie, and
B Castle, and
J Bellinger
September 1987,
Obstetrics and gynecology,
