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It was previously shown that rat tracheal explants first exposed to cigarette smoke and then to amosite asbestos take up more asbestos fibers than explants exposed to air and asbestos. To examine the mechanism of this process, the same experimental design was followed but test groups were added in which the asbestos was mixed with catalase or superoxide dismutase, scavengers of active oxygen species, or deferoxamine, an iron chelator that prevents formation of hydroxyl radical. All three agents protected against the cigarette smoke effect. Heat inactivated catalase or superoxide dismutase was not protective. These observations indicate that active oxygen species, probably derived from the cigarette smoke, play a role in smoke-mediated fiber transport into tracheobronchial epithelia.
A Churg, and
J Hobson, and
K Berean, and
J Wright
November 2003,
American journal of respiratory and critical care medicine,
A Churg, and
J Hobson, and
K Berean, and
J Wright
October 1987,
Environmental research,
A Churg, and
J Hobson, and
K Berean, and
J Wright
September 1998,
The American journal of physiology,
A Churg, and
J Hobson, and
K Berean, and
J Wright
April 2001,
American journal of respiratory cell and molecular biology,
A Churg, and
J Hobson, and
K Berean, and
J Wright
April 1986,
The American journal of pathology,
A Churg, and
J Hobson, and
K Berean, and
J Wright
January 1988,
Experimental lung research,
A Churg, and
J Hobson, and
K Berean, and
J Wright
September 2023,
Antioxidants (Basel, Switzerland),
A Churg, and
J Hobson, and
K Berean, and
J Wright
October 2005,
American journal of respiratory cell and molecular biology,
A Churg, and
J Hobson, and
K Berean, and
J Wright
November 1990,
Sangyo igaku. Japanese journal of industrial health,
A Churg, and
J Hobson, and
K Berean, and
J Wright
January 1992,
Journal of toxicology and environmental health,
