COPD exacerbation is associated with a high mortality rate and severe decrease in the QOL.Most medical expenses associated with COPD involve treatment costs related to exacerbation.However, the identification of pre-exacerbation changes in respiratory conditions from self controlled range, risk assessment, and multidisciplinary integrated respiratory care intervention could truly stabilize the condition of a patient with COPD and thus decrease the frequency of exacerbation.Such a decrease would be expected to lead to a high QOL, better COPD survival rate, and medical economic benefits.In addition, a reduced frequency of exacerbation would increase the stability of a patient's condition, allowing the continuation of effective pulmonary rehabilitation and maintenance of beneficial physical activity.