BIOMAT Database Logo BIOMAT Database Logo

Are blood eosinophil number and activity important for the development of the late asthmatic reaction after allergen challenge? 1989

P Venge, and R Dahl
Dept of Clinical Chemistry, University Hospital, Uppsala, Sweden.

A role for eosinophils in chronic asthma has recently gained substantial support. We hypothesized that in addition to eosinophil chemoattractants released in the lung, the availability of a sufficient number of blood eosinophils to be recruited and their increased activity are prerequisites for the development of asthma. To test this hypothesis the blood eosinophil number and serum levels of ECP (eosinophil cationic protein were measured before allergen challenge of 13 allergic asthmatics. Each individual was pretreated with either placebo or four inhalant anti-asthmatic drugs at random and blind in order to modulate the late asthmatic reaction (LAR). Irrespective of premedication the blood eosinophil number and serum-ECP levels were significantly higher before challenge when the challenge resulted in LAR. Only corticosteroids abrogated the development of LAR and also significantly reduced eosinophil activity as measured by serum-ECP. Thus the inherent activity of a sufficient number of eosinophils may be important determinants for the expression of allergic asthma.

UI MeSH Term Description Entries
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008176 Lung Volume Measurements Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle. Lung Capacities,Lung Volumes,Capacity, Lung,Lung Capacity,Lung Volume,Lung Volume Measurement,Measurement, Lung Volume,Volume, Lung
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001798 Blood Proteins Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins. Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D001985 Bronchial Provocation Tests Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma. Allergen Bronchial Provocation Tests,Allergen Challenge, Endobronchial,Antigen Bronchial Provocation Tests,Bronchial Allergen Challenge,Bronchial Challenge Tests,Inhalation Provocation Tests,Provocation Tests, Bronchial,Endobronchial Challenge Tests,Allergen Challenge, Bronchial,Allergen Challenges, Bronchial,Allergen Challenges, Endobronchial,Bronchial Allergen Challenges,Bronchial Challenge Test,Bronchial Provocation Test,Challenge Test, Bronchial,Challenge Test, Endobronchial,Challenge Tests, Bronchial,Challenge Tests, Endobronchial,Challenge, Bronchial Allergen,Challenge, Endobronchial Allergen,Challenges, Bronchial Allergen,Challenges, Endobronchial Allergen,Endobronchial Allergen Challenge,Endobronchial Allergen Challenges,Endobronchial Challenge Test,Inhalation Provocation Test,Provocation Test, Bronchial,Provocation Test, Inhalation,Provocation Tests, Inhalation,Test, Bronchial Challenge,Test, Bronchial Provocation,Test, Endobronchial Challenge,Test, Inhalation Provocation,Tests, Bronchial Challenge,Tests, Bronchial Provocation,Tests, Endobronchial Challenge,Tests, Inhalation Provocation
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004804 Eosinophils Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin. Eosinophil
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

P Venge, and R Dahl
Early and late asthmatic reaction after allergen challenge.
February 1994, Respiratory medicine,
P Venge, and R Dahl
Development of late asthmatic reactions after allergen or exercise challenge tests.
December 1980, European journal of respiratory diseases,
P Venge, and R Dahl
The occurrence of late asthmatic response to exercise after allergen challenge.
October 1998, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
P Venge, and R Dahl
The allergen specificity of the late asthmatic reaction.
March 2010, Allergy,
P Venge, and R Dahl
Late asthmatic responses after exercise challenge are reproducible.
June 1991, The Journal of allergy and clinical immunology,
P Venge, and R Dahl
The late asthmatic response to allergen challenge--Part I.
May 1986, Annals of allergy,
P Venge, and R Dahl
The late asthmatic response to allergen challenge--Part II.
May 1986, Annals of allergy,
P Venge, and R Dahl
Late asthmatic reactions and bronchial variability after challenge with low doses of allergen.
November 1988, Clinical allergy,
P Venge, and R Dahl
[Concentration of eosinophil cationic protein in blood serum during early and late asthmatic reaction].
January 1995, Pneumonologia i alergologia polska,
P Venge, and R Dahl
Lack of effect of cetirizine on early and late asthmatic response after allergen challenge.
August 1994, The Journal of allergy and clinical immunology,
Copied contents to your clipboard!