BIOMAT Database Logo BIOMAT Database Logo

Contribution of Gray and White Matter Abnormalities to Cognitive Impairment in Multiple Sclerosis. 2016

Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Department of Neurology, The General Hospital of Chinese People's Liberation Army, Fuxing Road 28, Haidian District, Beijing 100853, China. zhangxiaofei@301hospital.com.cn.

Patients with multiple sclerosis (MS) commonly exhibit cognitive impairments (CI). However, the neural mechanisms underlying CI remain unclear. The current study applied diffusion tensor imaging (DTI) and voxel-based morphometric (VBM) magnetic resonance imaging (MRI) techniques to evaluate differences in white matter (WM) integrity and gray matter (GM) volume between MS patients with CI and MS patients with cognitive preservation (CP). Neuropsychological assessment and MRI were obtained from 39 relapsing-remitting MS (RRMS) patients and 29 healthy controls (HCs). Patients were classified as CI or CP according to cognitive ability, and demographic characteristics and MRI images were compared. Compared with HCs, MS patients exhibited widespread damage in WM integrity, and GM loss in several regions. Compared with CP patients, CI patients exhibited more extensive WM impairments, particularly in the corpus callosum, cerebellar peduncle, corona radiata, optic radiation, superior longitudinal fasciculus, anterior limb of the internal capsule, and cingulate, as well as decreased GM volume in the bilateral caudate, left insula and right temporal lobe. MS patients with CI exhibited more significant structural abnormalities than those with CP. Widespread impairments of WM integrity and selective GM atrophy both appear to be associated with impaired cognition in RRMS.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control
D056324 Diffusion Tensor Imaging The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules. Diffusion Tractography,DTI MRI,Diffusion Tensor MRI,Diffusion Tensor Magnetic Resonance Imaging,Diffusion Tensor MRIs,Imaging, Diffusion Tensor,MRI, Diffusion Tensor,Tractography, Diffusion
D060825 Cognitive Dysfunction Diminished or impaired mental and/or intellectual function. Cognitive Disorder,Mild Cognitive Impairment,Cognitive Decline,Cognitive Impairments,Mental Deterioration,Cognitive Declines,Cognitive Disorders,Cognitive Dysfunctions,Cognitive Impairment,Cognitive Impairment, Mild,Cognitive Impairments, Mild,Decline, Cognitive,Declines, Cognitive,Deterioration, Mental,Deteriorations, Mental,Disorder, Cognitive,Disorders, Cognitive,Dysfunction, Cognitive,Dysfunctions, Cognitive,Impairment, Cognitive,Impairment, Mild Cognitive,Impairments, Cognitive,Impairments, Mild Cognitive,Mental Deteriorations,Mild Cognitive Impairments
D020529 Multiple Sclerosis, Relapsing-Remitting The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914) Multiple Sclerosis, Acute Relapsing,Relapsing-Remitting Multiple Sclerosis,Acute Relapsing Multiple Sclerosis,Remitting-Relapsing Multiple Sclerosis,Multiple Sclerosis, Relapsing Remitting,Multiple Sclerosis, Remitting-Relapsing,Relapsing Remitting Multiple Sclerosis,Remitting Relapsing Multiple Sclerosis

Related Publications

Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Contribution of Gray Matter Atrophy and White Matter Damage to Cognitive Impairment in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients.
March 2021, Diagnostics (Basel, Switzerland),
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
NODDI, diffusion tensor microstructural abnormalities and atrophy of brain white matter and gray matter contribute to cognitive impairment in multiple sclerosis.
February 2023, Journal of neurology,
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis.
September 2013, Multiple sclerosis (Houndmills, Basingstoke, England),
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Gray matter networks and cognitive impairment in multiple sclerosis.
March 2019, Multiple sclerosis (Houndmills, Basingstoke, England),
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
[Gray matter lesions and cognitive impairment in multiple sclerosis].
January 2014, Rinsho shinkeigaku = Clinical neurology,
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
White matter hemodynamic abnormalities precede sub-cortical gray matter changes in multiple sclerosis.
July 2009, Journal of the neurological sciences,
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis.
March 2006, Neurology,
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Cognitive impairment and memory disorders in relapsing-remitting multiple sclerosis: the role of white matter, gray matter and hippocampus.
July 2015, Journal of neurology,
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Modeling the relationship among gray matter atrophy, abnormalities in connecting white matter, and cognitive performance in early multiple sclerosis.
April 2015, AJNR. American journal of neuroradiology,
Xiaofei Zhang, and Fangfang Zhang, and Dehui Huang, and Lei Wu, and Lin Ma, and Hua Liu, and Yujun Zhao, and Shengyuan Yu, and Jiong Shi
Multiple white matter tract abnormalities underlie cognitive impairment in RRMS.
February 2012, NeuroImage,
Copied contents to your clipboard!