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Treatment of metastatic malignant melanoma with dacarbazine, vindesine and cisplatin. 1989
D Pectasides, and
H Yianniotis, and
N Alevizakos, and
D Bafaloukos, and
V Barbounis, and
J Varthalitis, and
M Dimitriadis, and
A Athanassiou
Department of Medical Oncology, Metaxas Memorial Cancer Hospital, Piraeus, Greece.
Twenty-seven patients with disseminated malignant melanoma were treated monthly with cisplatin (CDDP) 120 mg m-2 on day 1, vindesine (VDS) 3 mg m-2 on day 2 and dacarbazine (DTIC) 250 mg m-2 on days 2-6. None of them had received prior chemotherapy. All patients are evaluable for response and toxicity. There were five (19%) complete (CR) and seven (26%) partial (PR) responses for a total response rate of 45%. We conclude that the combination of DTIC, VDS and CDDP is capable of producing a relatively high rate of response in patients with advanced metastatic malignant melanoma, but responses are short.
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