The aim was to assess the effects of sex and age on fatigability and recovery from sustained maximal voluntary contraction (MVC) of the knee extensor muscles. The central (central activation ratio (CAR) and electrical activity amplitude) and peripheral (electrically evoked torque and muscle contractile properties) factors contributing to fatigue and recovery of 24 young adults (12 males) aged 23.2±3.6years and 20 older adults (12 males) aged 70.6±4.4years were compared. The increase in central and peripheral fatigue was greater (p⩽0.01) in the young adults vs the older adults. Sex differences (p=0.002) regarding MVC were attributed to the greater (p<0.01) peripheral fatigue of males vs females. The recovery rate of MVC was greater (p<0.001) in the young adults vs the older adults, with no sex effect. The recovery of MVC was correlated with the CAR in older adults (p=0.001). Thus, the greater endurance observed with age is caused by differences in central and peripheral mechanisms, whereas the greater endurance in females is caused by a difference in a mechanism located within the muscle. The impaired recovery from fatigue in older adults relied more on the recovery of central factors.