BIOMAT Database Logo BIOMAT Database Logo

[Effects of clopheline on impulse activity of neurons in the midbrain and dorsal horn of the spinal cord]. 1989

A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze

Clophelin (1-5 mg/kg) suppresses spinal dorsal horn neuronal nociceptive responses but does not change their touch stimuli reactions in unanesthetized curarized cats. This effect is steady to naloxone (1 mg/kg), yohimbine (5 mg/kg) and removal by prazosin (1 mg/kg). Clophelin depresses nociceptive responses of the central gray matter neurones which generalized pain impulses in the supraspinal structures.

UI MeSH Term Description Entries
D008636 Mesencephalon The middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems. Midbrain,Mesencephalons,Midbrains
D009270 Naloxone A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. MRZ 2593-Br,MRZ-2593,Nalone,Naloxon Curamed,Naloxon-Ratiopharm,Naloxone Abello,Naloxone Hydrobromide,Naloxone Hydrochloride,Naloxone Hydrochloride Dihydride,Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Narcan,Narcanti,Abello, Naloxone,Curamed, Naloxon,Dihydride, Naloxone Hydrochloride,Hydrobromide, Naloxone,Hydrochloride Dihydride, Naloxone,Hydrochloride, Naloxone,MRZ 2593,MRZ 2593 Br,MRZ 2593Br,MRZ2593,Naloxon Ratiopharm
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D009619 Nociceptors Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM. Pain Receptors,Receptors, Pain,Nociceptive Neurons,Neuron, Nociceptive,Neurons, Nociceptive,Nociceptive Neuron,Nociceptor,Pain Receptor
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D011224 Prazosin A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION. Furazosin,Minipress,Pratsiol,Prazosin HCL,Prazosin Hydrochloride,HCL, Prazosin,Hydrochloride, Prazosin
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D003000 Clonidine An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION. Catapres,Catapresan,Catapressan,Chlophazolin,Clofelin,Clofenil,Clonidine Dihydrochloride,Clonidine Hydrochloride,Clonidine Monohydrobromide,Clonidine Monohydrochloride,Clopheline,Dixarit,Gemiton,Hemiton,Isoglaucon,Klofelin,Klofenil,M-5041T,ST-155,Dihydrochloride, Clonidine,Hydrochloride, Clonidine,M 5041T,M5041T,Monohydrobromide, Clonidine,Monohydrochloride, Clonidine,ST 155,ST155
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013116 Spinal Cord A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER. Coccygeal Cord,Conus Medullaris,Conus Terminalis,Lumbar Cord,Medulla Spinalis,Myelon,Sacral Cord,Thoracic Cord,Coccygeal Cords,Conus Medullari,Conus Terminali,Cord, Coccygeal,Cord, Lumbar,Cord, Sacral,Cord, Spinal,Cord, Thoracic,Cords, Coccygeal,Cords, Lumbar,Cords, Sacral,Cords, Spinal,Cords, Thoracic,Lumbar Cords,Medulla Spinali,Medullari, Conus,Medullaris, Conus,Myelons,Sacral Cords,Spinal Cords,Spinali, Medulla,Spinalis, Medulla,Terminali, Conus,Terminalis, Conus,Thoracic Cords

Related Publications

A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
[Evoked neuron impulse activity in the spinal cord dorsal horn].
January 1970, Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
[Characteristics of background impulse activity of separate elements of the spinal cord dorsal horn].
June 1971, Biulleten' eksperimental'noi biologii i meditsiny,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
Effects of noradrenergic agonists on superficial dorsal horn neurons in the cat spinal cord.
July 1998, Brain research,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
[Effects of morphine on the activity of various dorsal horn neurons of the spinal cord involved in nociception].
January 1979, L'Encephale,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
[Nociceptive neurons in the dorsal horn of the spinal cord].
July 1982, Masui. The Japanese journal of anesthesiology,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
Tonic descending influences on cat spinal cord dorsal horn neurons.
January 1983, Somatosensory research,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
Dorsal root projections to dorsal horn neurons in the cat spinal cord.
February 1968, The Journal of comparative neurology,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
Intersegmental synchronization of spontaneous activity of dorsal horn neurons in the cat spinal cord.
February 2003, Experimental brain research,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
Neonatal rat spinal cord slice preparation: postsynaptic effects of neuropeptides on dorsal horn neurons.
October 1981, Brain research,
A A Zaĭtsev, and S M Butkhuzi, and V V Kolchin, and B T Moroz, and Z A Sakvarelidze
ErbB4+ spinal cord dorsal horn neurons process heat pain.
July 2022, Neuron,
Copied contents to your clipboard!