-transparent.png){kind=logo}
The cytochromes P-450, a family of heme proteins, play an important role in the oxidation of drugs and carcinogens, as well as endogenous substrates. We report the presence of cytochrome P-450 and associated mono-oxygenase activity in human brain regions and their selective enrichment in the brainstem. Immunocytochemical studies on human medulla with antibodies raised to phenobarbital-inducible rat liver cytochrome P-450 indicate that the enzyme is primarily localized in the neuronal cell bodies and to a lesser extent in the axons. These observations indicate that the human brain could be involved in metabolism of xenobiotics and endogenous compounds, mediated through cytochrome P-450.
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
May 1992,
Biochemical Society transactions,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
January 1988,
Xenobiotica; the fate of foreign compounds in biological systems,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
January 1984,
Biochemical pharmacology,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
January 1986,
IARC scientific publications,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
August 1989,
Biochimica et biophysica acta,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
January 1980,
Proceedings of the Western Pharmacology Society,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
January 1991,
Advances in applied microbiology,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
November 1993,
Biochemical Society transactions,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
October 1987,
Xenobiotica; the fate of foreign compounds in biological systems,
V Ravindranath, and
H K Anandatheerthavarada, and
S K Shankar
November 1987,
Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete,
