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Because recombinant interleukin 2 (rIL-2) and recombinant alpha-interferon (rIFN-alpha) exhibit synergistic antitumor activity in C3HMT1820 T-cell lymphoma and B16 melanoma tumor systems, we have performed a Phase I study of this combination in 55 patients with advanced malignancies for whom no standard therapy exists. Successive groups of greater than or equal to 4 patients have been entered into 12 dose levels (1A-3D), with dose levels 1-3 referring to doses of rIL-2 of 0.1, 0.5, and 2.0 x 10(6) units/m2, respectively, and dose levels A-D referring to doses of recombinant human alpha 2a-interferon (rHuIFN-alpha 2a) of 0, 0.1, 1.0, and 10.0 x 10(6) units/m2. Both agents were given on Mondays, Wednesdays, and Fridays, with rIL-2 being given as i.v. bolus injections and rHuIFN-alpha 2a being given intramuscularly. Myelosuppression was dose-limiting and was related primarily to the dose of rHuIFN-alpha 2a. The maximum-tolerated dose level was reached at a dose of rIL-2 of 2.0 x 10(6) units/m2 and of rHuIFN-alpha 2a of 10.0 x 10(6) units/m2 (dose level 3D). At this dose level, 3/6 patients developed grade 3 neutropenia (absolute granulocyte count less than 1 x 10(9)/liter). Myelosuppression was transient, with no documented infections being associated with neutropenia. Hypotension was mild; a single patient was treated with a vasopressor, but all other cases of hypotension responded to fluid administration. No significant pulmonary toxicity was produced. Fever, chills, and malaise were universal but not dose-limiting. Three partial responses and one minor response were observed in patients with malignant melanoma, renal cell carcinoma, and breast cancer. Immunological studies suggested that natural killer activity was related to both the dose of rIL-2 and the dose of rHuIFN-alpha 2a, with natural killer activity being positively related to the dose of rIL-2 and maximal at the lowest dose of rHuIFN-alpha 2a of 0.1 x 10(6) units/m2.
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
December 1990,
Journal of biological response modifiers,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
August 1986,
International journal of radiation oncology, biology, physics,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
January 1992,
Journal of immunotherapy : official journal of the Society for Biological Therapy,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
January 1998,
Tumori,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
August 1987,
Cancer research,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
July 1997,
Journal of immunotherapy (Hagerstown, Md. : 1997),
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
August 1998,
British journal of cancer,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
October 1997,
American journal of clinical oncology,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
December 1987,
Tumori,
G T Budd, and
B Osgood, and
B Barna, and
J M Boyett, and
J Finke, and
S V Medendorp, and
S Murthy, and
C Novak, and
J Sergi, and
R Tubbs
June 1992,
American heart journal,
