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Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal. 2017
Mathieu Gendrot, and
Silman Diawara, and
Marylin Madamet, and
Mame Bou Kounta, and
Sébastien Briolant, and
Khalifa Ababacar Wade, and
Mansour Fall, and
Nicolas Benoit, and
Aminata Nakoulima, and
Rémy Amalvict, and
Yaya Diémé, and
Bécaye Fall, and
Boubacar Wade, and
Bakary Diatta, and
Bruno Pradines
Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.
Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the Plasmodium falciparum multidrug resistance 6 gene (Pfmdr6) and the ex vivo susceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine.
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