BIOMAT Database Logo BIOMAT Database Logo

Relation between lymphocytotoxic antibodies, anti-DNA antibodies and a common anti-DNA antibody idiotype PR4 in patients with systemic lupus erythematosus, their relatives and spouses. 1989

S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Department of Rheumatology Research, University College and Middlesex School of Medicine, London, England.

Forty-two patients with systemic lupus erythematosus (SLE), 65 of their healthy relatives and 20 spouses were studied for the presence of lymphocytotoxic antibodies (LCA), anti-lymphocyte antibodies (ALA), antibodies to DNA and a common idiotype (Id) PR4. Seventy-one per cent of the patients had positive levels of LCA, and in 34% the PR4 Id was detected; normal levels were found in their families. Anti-PR4, an anti-Id, failed to block the lymphocytotoxic activity in those nine patients who both carried the Id and had LCA. This indicates that the Id was not present on LCA. There was no correlation between anti-DNA antibodies and LCA, suggesting that different mechanisms are involved in their expression.

UI MeSH Term Description Entries
D007130 Immunoglobulin Idiotypes Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains. Idiotypes, Immunoglobulin,Ig Idiotypes,Idiotype, Ig,Idiotype, Immunoglobulin,Idiotypes, Ig,Ig Idiotype,Immunoglobulin Idiotype
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008297 Male Males
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005190 Family A social group consisting of parents or parent substitutes and children. Family Life Cycles,Family Members,Family Life Cycle,Family Research,Filiation,Kinship Networks,Relatives,Families,Family Member,Kinship Network,Life Cycle, Family,Life Cycles, Family,Network, Kinship,Networks, Kinship,Research, Family
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000961 Antilymphocyte Serum Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION. ATGAM,Antilymphoblast Globulins,Antilymphocyte Antibodies,Antilymphocyte Globulin,Lymphocytotoxic Antibodies,Anti-Thymocyte Globulin,Antilymphocyte Immunoglobulin,Antithymocyte Globulin,Antithymoglobulin,Lymphocyte Immune Globulin, Anti-Thymocyte Globulin,Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine),Pressimmune,Anti Thymocyte Globulin,Anti-Thymocyte Globulins,Antibodies, Antilymphocyte,Antibodies, Lymphocytotoxic,Antibody, Antilymphocyte,Antibody, Lymphocytotoxic,Antilymphoblast Globulin,Antilymphocyte Antibody,Antilymphocyte Globulins,Antilymphocyte Immunoglobulins,Antilymphocyte Serums,Antithymocyte Globulins,Antithymoglobulins,Globulin, Anti-Thymocyte,Globulin, Antilymphoblast,Globulin, Antilymphocyte,Globulin, Antithymocyte,Globulins, Anti-Thymocyte,Globulins, Antilymphoblast,Globulins, Antilymphocyte,Globulins, Antithymocyte,Immunoglobulin, Antilymphocyte,Immunoglobulins, Antilymphocyte,Lymphocyte Immune Globulin, Anti Thymocyte Globulin,Lymphocytotoxic Antibody,Serum, Antilymphocyte,Serums, Antilymphocyte
D000974 Antibodies, Antinuclear Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease. Anti-DNA Antibodies,Antibodies, Anti-DNA,Antinuclear Antibodies,Antinuclear Autoantibodies,Antinuclear Autoantibody,Antinuclear Factors,Antinuclear Antibody,Antinuclear Factor,Anti DNA Antibodies,Antibody, Antinuclear,Autoantibody, Antinuclear,Factor, Antinuclear

Related Publications

S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Anti-DNA idiotype- and anti-idiotype-specific T cell responses in patients with systemic lupus erythematosus and their first-degree relatives.
December 1990, Clinical and experimental immunology,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Binding of anti-DNA antibodies to oxidatively damaged DNA in spouses and relatives of patients with systemic lupus erythematosus.
July 1994, Immunology letters,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Lymphocytotoxic antibodies in patients with systemic lupus erythematosus.
June 1974, Clinical and experimental immunology,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Lymphocytotoxic antibodies in patients with systemic lupus erythematosus & their household contacts.
June 1990, The Indian journal of medical research,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Lymphocytotoxic antibodies in systemic lupus erythematosus patients and their relatives: reactivity with the HLA antigenic molecular complex.
March 1980, Arthritis and rheumatism,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
The role of anti-DNA idiotype antibodies in systemic lupus erythematosus.
January 1990, Critical reviews in immunology,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Anti-nucleic acid antibodies in systemic lupus erythematosus patients and their families. Incidence and correlation with lymphocytotoxic antibodies.
November 1975, The Journal of clinical investigation,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Lymphocytotoxic antibodies in systemic lupus erythematosus: their clinical significance.
January 1979, Journal of clinical pathology. Supplement (Royal College of Pathologists),
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
The frequency of a common anti-DNA antibody idiotype (16/6) in different populations of patients with systemic lupus erythematosus.
July 1991, The Journal of rheumatology,
S H Le Page, and W Williams, and D Parkhouse, and G Cambridge, and L MacKenzie, and P M Lydyard, and D A Isenberg
Lymphocytotoxic antibodies in mexican patients with systemic lupus erythematosus and their families relationship of disease activity in the probands to antibody cytotoxicity in their relatives.
January 1981, Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
Copied contents to your clipboard!