Biomaterial Database

Sudden-onset deafness. Serodiagnosis of recent meningococcal infection. 1989

M W Kline, and C E Frasch

Department of Pediatrics, St. Louis University School of Medicine, Missouri.

An 8.5-year-old boy was evaluated 3 weeks after the occurrence of a febrile illness associated with sudden-onset deafness. An extensive diagnostic evaluation was largely unrewarding. However, unusual epidemiologic features of the case and cerebrospinal fluid abnormalities suggested meningococcal meningitis as the probable etiology. Serologic studies confirmed recent meningococcal infection. The potential etiologies of sudden acquired deafness are diverse, but a thorough evaluation is warranted and may be rewarding, even if it is initiated weeks after onset of deafness.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008585	Meningitis, Meningococcal	A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)	Meningitis, Neisseria,Neisseria Meningitis,Meningitis, Meningococcal, Serogroup A,Meningitis, Meningococcal, Serogroup B,Meningitis, Meningococcal, Serogroup C,Meningitis, Meningococcal, Serogroup W-135,Meningitis, Meningococcal, Serogroup W135,Meningitis, Meningococcal, Serogroup Y,Meningitis, Meningococcic,Meningococcal Meningitis, Serogroup A,Meningococcal Meningitis, Serogroup B,Meningococcal Meningitis, Serogroup C,Meningococcal Meningitis, Serogroup W-135,Meningococcal Meningitis, Serogroup W135,Meningococcal Meningitis, Serogroup Y,Serogroup A Meningococcal Meningitis,Serogroup B Meningococcal Meningitis,Serogroup C Meningococcal Meningitis,Serogroup W-135, Meningococcal Meningitis,Serogroup W135, Meningococcal Meningitis,Serogroup Y, Meningococcal Meningitis,Meningococcal Meningitis,Meningococcal Meningitis, Serogroup W 135,Neisseria Meningitides,Serogroup W 135, Meningococcal Meningitis
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D003639	Hearing Loss, Sudden	Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.	Deafness, Sudden,Sudden Deafness,Sudden Hearing Loss
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012529	Saudi Arabia	A country located in the Middle East, bordering the Persian Gulf and the Red Sea, north of Yemen. The capital is Riyadh.	Kingdom of Saudi Arabia