Biomaterial Database

Focal Signet Ring Cell High-Grade Prostatic Intraepithelial Neoplasia on Needle Biopsy. 2017

Guang-Qian Xiao, and Pamela D Unger

1 Keck Medical Center of the University of Southern California, Los Angeles, CA, USA.

Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma on needle biopsy and demonstrated the existence of this type of HGPIN variant. The differentiation between HGPIN and intraductal carcinoma of prostate is also discussed.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011471	Prostatic Neoplasms	Tumors or cancer of the PROSTATE.	Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D001707	Biopsy, Needle	Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.	Aspiration Biopsy,Puncture Biopsy,Aspiration Biopsies,Biopsies, Aspiration,Biopsies, Needle,Biopsies, Puncture,Biopsy, Aspiration,Biopsy, Puncture,Needle Biopsies,Needle Biopsy,Puncture Biopsies
D018279	Carcinoma, Signet Ring Cell	A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.	Signet Ring Cell Carcinoma
D019048	Prostatic Intraepithelial Neoplasia	A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.	Neoplasia, Prostatic Intraepithelial,Intraepithelial Prostatic Neoplasia,Prostatic Intraepithelial Neoplasms,Intraepithelial Neoplasia, Prostatic,Intraepithelial Neoplasm, Prostatic,Intraepithelial Neoplasms, Prostatic,Intraepithelial Prostatic Neoplasias,Neoplasia, Intraepithelial Prostatic,Neoplasm, Prostatic Intraepithelial,Neoplasms, Prostatic Intraepithelial,Prostatic Intraepithelial Neoplasias,Prostatic Intraepithelial Neoplasm,Prostatic Neoplasia, Intraepithelial