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Fructose-1,6-diphosphate (FDP) was given to 30 patients with chronic heart failure (CHF) caused by various kinds of heart diseases with the purpose to evaluate the effects of FDP on CHF patients. Definite hemodynamic and clinical improvement has been found in this group. CO increased by 1.61 +/- 0.31 L/Min (35%) (P less than 0.01) PCWP decreased by 5.5 +/- 1.08 mmHg (31%); mean PAP decreased by 5.8 +/- 2.07 mmHg (P less than 0.05). EF increased by 6.9 +/- 1.5 (15.1%) as shown by echocardiography and the peak effect of the drug appeared at 2 hours after administration. The results showed that FDP is effective in the treatment of heart failure, especially in patients with dysfunction of other organs.
J P Sun, and
G Zhi, and
X S Yang
August 1989,
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques,
J P Sun, and
G Zhi, and
X S Yang
August 1983,
Research communications in chemical pathology and pharmacology,
J P Sun, and
G Zhi, and
X S Yang
February 1984,
Clinical biochemistry,
J P Sun, and
G Zhi, and
X S Yang
February 1999,
Veterinary and human toxicology,
J P Sun, and
G Zhi, and
X S Yang
January 1977,
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression,
J P Sun, and
G Zhi, and
X S Yang
October 1954,
The Journal of biological chemistry,
J P Sun, and
G Zhi, and
X S Yang
January 2000,
Respiration; international review of thoracic diseases,
J P Sun, and
G Zhi, and
X S Yang
April 1992,
Biochemical pharmacology,
J P Sun, and
G Zhi, and
X S Yang
May 1963,
Biochimica et biophysica acta,
J P Sun, and
G Zhi, and
X S Yang
December 1970,
La Clinica terapeutica,
