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The ability of various 1-methyl-4-phenylpyridinium (MPP+) analogs to inhibit the uptake of tritium labeled dopamine and MPP+ by synaptosomes prepared from neostriata of male C57 Black mice was measured and compared with their dopaminergic neurotoxic potential which was estimated by an in vivo intracerebral microdialysis technique. The correlation observed between these two properties suggests that nerve terminal uptake is an important step in the expression of the nigrostriatal toxicity of structural analogs of MPP+. The uptake inhibition and neurotoxic properties of this series of compounds appear to be highly structurally sensitive and suggest that few nitrogenous bases will be potent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-type neurotoxins.
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
November 1986,
European journal of pharmacology,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
March 1992,
The Journal of pharmacology and experimental therapeutics,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
May 1992,
European journal of pharmacology,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
August 1997,
Journal of neuroscience research,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
March 2015,
The Journal of biological chemistry,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
January 1996,
Biological & pharmaceutical bulletin,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
March 1988,
Brain research,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
February 1989,
Journal of neurochemistry,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
April 1998,
Neuroscience letters,
E A Johnson, and
E Y Wu, and
H Rollema, and
R G Booth, and
A J Trevor, and
N Castagnoli
December 2010,
International journal of toxicology,
