BIOMAT Database Logo BIOMAT Database Logo

Otitis media in children: local immune response to nontypeable Haemophilus influenzae. 1989

H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Department of Pediatrics and Otolaryngology, School of Medicine, State University of New York at Buffalo 14222.

Twenty children experienced 30 episodes of otitis media with effusion due to nontypeable (NT) Haemophilus influenzae in the first 2 years of life. The local and systemic immune responses to homologous strains of NT H. influenzae were determined by an immunodot assay. Strain-specific immunoglobulin G (IgG) antibody predominated in the middle ear fluid (MEF). It was detected in 91% of the children, compared with IgM in 48% (P less than 0.005), IgA in 52% (P less than 0.005), and secretory IgA in 18% (P less than 0.005). The titer (log2) of NT H. influenzae-specific IgG antibody (mean +/- standard error, 8.2 +/- 0.1) exceeded the titers of IgM (3.4 +/- 0.1), IgA (3.7 +/- 0.1), and secretory IgA (1.2 +/- 0.3). NT H. influenzae-specific antibody was detected exclusively in MEFs of individuals who possessed homologous serum antibody. Although antibody titers in MEF declined over time, serum antibody titers remained stable. These data suggest that immunity to NT H. influenzae in the middle ear, in part, reflects systemic immunity. Whereas local antibody disappears after resolution of the infection, systemic antibody persists.

UI MeSH Term Description Entries
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D007223 Infant A child between 1 and 23 months of age. Infants
D010033 Otitis Media Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE. Middle Ear Inflammation,Inflammation, Middle Ear
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D004432 Ear, Middle The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat. Tympanic Cavity,Tympanum,Middle Ear,Cavities, Tympanic,Cavity, Tympanic,Ears, Middle,Middle Ears,Tympanic Cavities,Tympanums
D006193 Haemophilus influenzae A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Bacterium influenzae,Coccobacillus pfeifferi,Haemophilus meningitidis,Hemophilus influenzae,Influenza-bacillus,Mycobacterium influenzae
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000907 Antibodies, Bacterial Immunoglobulins produced in a response to BACTERIAL ANTIGENS. Bacterial Antibodies

Related Publications

H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Antibody response to outer membrane protein of nontypeable Haemophilus influenzae in otitis-prone children.
February 1993, The Journal of pediatrics,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae.
July 2016, Expert review of vaccines,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Evidence of functional cell-mediated immune responses to nontypeable Haemophilus influenzae in otitis-prone children.
January 2018, PloS one,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Human immune response to nontypeable Haemophilus influenzae in chronic bronchitis.
November 1997, The Journal of infectious diseases,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Biofilm biology and vaccine strategies for otitis media due to nontypeable Haemophilus influenzae.
February 2019, Journal of pediatric infectious diseases,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children.
August 2012, FEMS immunology and medical microbiology,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Australian Aboriginal Children with Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus influenzae Vaccine Antigens.
April 2017, Clinical and vaccine immunology : CVI,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Antibody response in experimental Haemophilus influenzae otitis media.
May 1986, Archives of otolaryngology--head & neck surgery,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Peptidoglycan isolated from nontypeable Haemophilus influenzae induces experimental otitis media in the chinchilla.
December 1994, The Journal of infectious diseases,
H Faden, and L Brodsky, and J Bernstein, and J Stanievich, and D Krystofik, and C Shuff, and J J Hong, and P L Ogra
Role of nontypeable Haemophilus influenzae in otitis media and chronic obstructive pulmonary disease.
January 2011, Advances in oto-rhino-laryngology,
Copied contents to your clipboard!