The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats. 2016

Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
Sichuan University, West China Hospital of Stomatology, Department of Orthodontics, State Key Laboratory of Oral Diseases, Chengdu, China.

The aim of this study was to explore the effect of capsaicin on expression patterns of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) and trigeminal subnucleus caudalis (Vc) following experimental tooth movement. Male Sprague-Dawley rats were used in this study and divided into small-dose capsaicin+force group, large-dose capsaicin+force group, saline+force group, and no force group. Closed coil springs were used to mimic orthodontic forces in all groups except for the no force group, in which springs were inactivated. Capsaicin and saline were injected into periodontal tissues. Rats were euthanized at 0 h, 12 h, 1 d, 3 d, 5 d, and 7 d following experimental tooth movement. Then, TG and Vc were obtained for immunohistochemical staining and western blotting against CGRP. Immunohistochemical results indicated that CGRP positive neurons were located in the TG, and CGRP immunoreactive fibers were distributed in the Vc. Immunohistochemical semiquantitative analysis and western blotting analysis demonstrated that CGRP expression levels both in TG and Vc were elevated at 12 h, 1 d, 3 d, 5 d, and 7 d in the saline + force group. However, both small-dose and large-dose capsaicin could decrease CGRP expression in TG and Vc at 1 d and 3 d following experimental tooth movement, as compared with the saline + force group. These results suggest that capsaicin could regulate CGRP expression in TG and Vc following experimental tooth movement in rats.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002211 Capsaicin An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS. 8-Methyl-N-Vanillyl-6-Nonenamide,Antiphlogistine Rub A-535 Capsaicin,Axsain,Capsaicine,Capsicum Farmaya,Capsidol,Capsin,Capzasin,Gelcen,Katrum,NGX-4010,Zacin,Zostrix,8 Methyl N Vanillyl 6 Nonenamide,NGX 4010,NGX4010
D005157 Facial Pain Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES. Craniofacial Pain,Myofacial Pain,Orofacial Pain,Pain, Facial,Face Pain,Neuralgic Facial Pain,Facial Pain, Neuralgic,Pain, Craniofacial,Pain, Face,Pain, Myofacial,Pain, Neuralgic Facial,Pain, Orofacial
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012668 Trigeminal Ganglion The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves. Gasserian Ganglion,Semilunar Ganglion,Gasser's Ganglion,Trigeminal Ganglia,Ganglia, Trigeminal,Ganglion, Gasser's,Ganglion, Gasserian,Ganglion, Semilunar,Ganglion, Trigeminal,Gasser Ganglion,Gassers Ganglion,Semilunar Ganglions,Trigeminal Ganglias,Trigeminal Ganglions
D012965 Sodium Chloride A ubiquitous sodium salt that is commonly used to season food. Sodium Chloride, (22)Na,Sodium Chloride, (24)NaCl
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
March 2005, Brain research,
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
February 2015, Shanghai kou qiang yi xue = Shanghai journal of stomatology,
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
May 2012, Indian journal of experimental biology,
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
March 2005, Cephalalgia : an international journal of headache,
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
February 2008, Biomedical research (Tokyo, Japan),
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
March 2010, Anatomical record (Hoboken, N.J. : 2007),
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
January 2009, Archives of oral biology,
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
January 2017, Bioelectromagnetics,
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
February 2015, European journal of oral sciences,
Yang Zhou, and Hu Long, and Niansong Ye, and Lina Liao, and Xin Yang, and Fan Jian, and Yan Wang, and Wenli Lai
November 2020, Neurological research,
Copied contents to your clipboard!