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The cytotoxicity and the uptake of three 4-quinolones--pefloxacin, ciprofloxacin, and ofloxacin--were investigated in primary cultures of rat hepatocytes. As assessed by intracellular enzyme release in culture media, pefloxacin at concentration 400 mg/l and ciprofloxacin at 200 mg/l were found to be hepatotoxins. However, concentration ofloxacin up to 400 mg/l were not hepatotoxic. After 48 h incubation, the remaining antibiotic concentrations in the culture medium as determined by HPLC were 55%, 45%, and 35% for ofloxacin, ciprofloxacin, and pefloxacin, respectively. Comparisons of quinolone concentrations in the hepatocyte culture medium determined by HPLC and correspondent antibacterial activities determined by microbiological assays did not reveal any metabolites with antibacterial activity other than those which have been identified from intact animals.
P Nordmann, and
A Pechinot, and
A Kazmierczak
November 1999,
Free radical research,
P Nordmann, and
A Pechinot, and
A Kazmierczak
April 1980,
Toxicology and applied pharmacology,
P Nordmann, and
A Pechinot, and
A Kazmierczak
January 1990,
Biochemistry international,
P Nordmann, and
A Pechinot, and
A Kazmierczak
April 1993,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
P Nordmann, and
A Pechinot, and
A Kazmierczak
January 1990,
Presse medicale (Paris, France : 1983),
P Nordmann, and
A Pechinot, and
A Kazmierczak
June 1989,
Pathologie-biologie,
P Nordmann, and
A Pechinot, and
A Kazmierczak
November 1991,
Toxicology letters,
P Nordmann, and
A Pechinot, and
A Kazmierczak
December 1981,
Biochemical pharmacology,
P Nordmann, and
A Pechinot, and
A Kazmierczak
June 1986,
The American journal of physiology,
P Nordmann, and
A Pechinot, and
A Kazmierczak
April 1987,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
